Individual Efficacy and Community Impact of Ivermectin, Diethylcarbamazine, and Albendazole Mass Drug Administration for Lymphatic Filariasis Control in Fiji: A Cluster Randomized Trial
نویسندگان
چکیده
Abstract Background Bancroftian filariasis remains endemic in Fiji despite >10 years of mass drug administration (MDA) using diethylcarbamazine and albendazole (DA). The addition ivermectin to this combination (IDA) has improved efficacy microfilarial clearance at 12 months individually randomized trials nocturnal transmission settings, but impact a setting diurnally subperiodic filarial not been evaluated. Methods This cluster study compared the individual community IDA vs DA as MDA for lymphatic 35 villages on 2 islands Fiji. Participants were tested enrollment circulating antigen and, if positive, microfilariae. Weight-dosed treatment was offered according village randomization. Communities visited retested filariasis. Infected individuals from Rotuma 24 months. Results A total 3816 participants enrolled 3616 treated. At months, microfilariae achieved 72 111 detected with infection baseline, no difference between groups: DA, 69.2% (95% confidence interval [CI], 57.2%–79.1%) IDA, 62.5% CI, 43.6%–78.2%); risk difference, 11.3 % –10% 32.7%); P = .30. There groups prevalence or Conclusions We found following second annual round IDA. Possible explanations apparent lack benefit include parasite factors affecting clearance, higher than expected reinfection rates. Clinical Trials Registration: NCT03177993 Australian New Zealand Trial Registry: N12617000738325.
منابع مشابه
Lymphatic Filariasis Control in Tanzania: Effect of Repeated Mass Drug Administration with Ivermectin and Albendazole on Infection and Transmission
BACKGROUND In most countries of sub-Saharan Africa the control of lymphatic filariasis (LF) is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. Here we present the first detailed study on the effect of 3 repeated MDAs with this drug combination, as implemented by the Tanzanian National Lymphatic Filariasis Elimi...
متن کاملEfficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis.
BACKGROUND Available treatments for lymphatic filariasis (LF) are limited in their longterm clearance of microfilaria from the blood. The safety and efficacy of a single-dose triple-drug therapy of the antifilarial drugs diethylcarbamazine (DEC), ivermectin (IVM), and albendazole (ALB) for LF are unknown. METHODS We performed a pilot study to test the efficacy, safety, and pharmacokinetics of...
متن کاملThe Impact of Repeated Rounds of Mass Drug Administration with Diethylcarbamazine Plus Albendazole on Bancroftian Filariasis in Papua New Guinea
BACKGROUND This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region. METHODOLOGY/PRINCIPAL FINDINGS Residents of rural villages near Madang were studied prior to and one year after each of three rounds of MDA with diethyl...
متن کاملAuthor's response to reviews Title: Lymphatic filariasis control in Tanzania: Effect of six rounds of mass drug administration with ivermectin and albendazole on infection and transmission Authors:
متن کامل
Lymphatic filariasis control in Tanzania: effect of six rounds of mass drug administration with ivermectin and albendazole on infection and transmission
BACKGROUND Control of lymphatic filariasis (LF) in most countries of sub-Saharan Africa is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. We present findings from a detailed study on the effect of six rounds of MDA with this drug combination as implemented by the National Lymphatic Filariasis Elimination Progr...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2021
ISSN: ['1058-4838', '1537-6591']
DOI: https://doi.org/10.1093/cid/ciab202